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Pore geometry regulates early stage human bone marrow cell tissue formation and organisation

Abstract:

Porous architecture has a dramatic effect on tissue formation in porous biomaterials used in regenerative medicine. However, the wide variety of 3D structures used indicates there is a clear need for the optimal design of pore architecture to maximize tissue formation and ingrowth. Thus, the aim of this study was to characterize initial tissue growth solely as a function of pore geometry. We used an in vitro system with well-defined open pore slots of varying width, providing a 3D environment...

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Publisher copy:
10.1007/s10439-013-0748-z

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
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Journal:
Annals of Biomedical Engineering
Volume:
41
Issue:
5
Pages:
917-930
Publication date:
2013-05-05
DOI:
EISSN:
1573-9686
ISSN:
0090-6964
URN:
uuid:9b09705f-7abf-457a-a3b3-6271c67a4213
Source identifiers:
406656
Local pid:
pubs:406656

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