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Journal article

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.

Abstract:

Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been associated with a range of behavioural phenotypes. The underlying mechanisms are unclear but may involve changes in 5-HT receptor levels and/or signalling. The present study used a novel 5-HTT overexpressing transgenic mouse to test the hypothesis that variability in 5-HTT expression may alter 5-HT(2A) receptor function. In wildtype mice, the 5-HT(2) receptor agonist DOI increased regional brain mR...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuropharmacology
Volume:
54
Issue:
5
Pages:
776-783
Publication date:
2008-04-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:9b07ed72-25b0-49b3-8d9f-3b404c8a1507
Source identifiers:
185122
Local pid:
pubs:185122

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