Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.

Journal article

Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been associated with a range of behavioural phenotypes. The underlying mechanisms are unclear but may involve changes in 5-HT receptor levels and/or signalling. The present study used a novel 5-HTT overexpressing transgenic mouse to test the hypothesis that variability in 5-HTT expression may alter 5-HT(2A) receptor function. In wildtype mice, the 5-HT(2) receptor agonist DOI increased regional brain mR...

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Authors: Jennings, K; Sheward, W; Harmar, A; Sharp, T

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 54
• Issue: 5
• Pages: 776-783
• Publication date: 2008-04-01
• DOI: 10.1016/j.neuropharm.2007.12.001
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Receptor, Serotonin, 5-HT2A; Animals; Fluorobenzenes; Serotonin Receptor Agonists; Cytoskeletal Proteins; Serotonin Antagonists; Amphetamines; Analysis of Variance; Mice, Inbred C57BL; Genetic Variation; Brain; Ketanserin; Proto-Oncogene Proteins c-fos; Serotonin; Piperidines; Gene Expression; Mice, Transgenic; Dose-Response Relationship, Drug; Serotonin Plasma Membrane Transport Proteins; Protein Binding; Mice; Head Movements; Male; Nerve Tissue Proteins