Journal article icon

Journal article

Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria.

Abstract:

Store-operated Ca2+ channels in the plasma membrane (PM) are activated by the depletion of Ca2+ from the endoplasmic reticulum (ER) and constitute a widespread and highly conserved Ca2+ influx pathway. After store emptying, the ER Ca2+ sensor STIM1 forms multimers, which then migrate to ER-PM junctions where they activate the Ca2+ release-activated Ca2+ channel Orai1. Movement of an intracellular protein to such specialized sites where it gates an ion channel is without precedence, but the fu...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m110.174029

Authors


Singaravelu, K More by this author
Bakowski, D More by this author
de Brito, OM More by this author
Expand authors...
Journal:
The Journal of biological chemistry
Volume:
286
Issue:
14
Pages:
12189-12201
Publication date:
2011-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9b06d0c3-3da0-4eeb-88be-642106b16af7
Source identifiers:
112507
Local pid:
pubs:112507

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP