Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Journal article

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Authors: Feldmann, M; Andreakos, E; Smith, C; Bondeson, J; Yoshimura, S

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 61 Suppl 2
• Issue: SUPPL. 2
• Pages: ii13-ii18
• Publication date: 2002-11-01
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Cell Culture Techniques; I-kappa B Proteins; Immunity, Cellular; Dendritic Cells; Humans; Genetic Vectors; Lymphocyte Culture Test, Mixed; Antigen Presentation; NF-kappa B; Adenoviridae; Arthritis, Rheumatoid; Synovial Membrane