Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
- There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.
- Publication status:
- Annals of the rheumatic diseases
- 61 Suppl 2
- SUPPL. 2
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