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Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Abstract:
There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Andreakos, E More by this author
Bondeson, J More by this author
Yoshimura, S More by this author
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Journal:
Annals of the rheumatic diseases
Volume:
61 Suppl 2
Issue:
SUPPL. 2
Pages:
ii13-ii18
Publication date:
2002-11-05
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:9b06b108-1bd7-45cf-b4bc-5b3c75f9d856
Source identifiers:
223482
Local pid:
pubs:223482

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