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Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study.

Abstract:

OBJECTIVES: To test the hypothesis that remote ischaemic preconditioning (rIPC) reduces injury after cardiopulmonary bypass (CPB). DESIGN: Randomised study with an experimental model of CPB (3 h CPB with 2 h of cardioplegic arrest). Twelve 15 kg pigs were randomly assigned to control or rIPC before CPB and followed up for 6 h. INTERVENTION: rIPC was induced by four 5 min cycles of lower limb ischaemia before CPB. MAIN OUTCOME MEASURES: Troponin I, glial protein S-100B, lactate concentrations,...

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Publication status:
Published

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Publisher copy:
10.1136/hrt.2004.042366

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Konstantinov, IE More by this author
Cheung, MM More by this author
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Journal:
Heart (British Cardiac Society)
Volume:
92
Issue:
10
Pages:
1506-1511
Publication date:
2006-10-05
DOI:
EISSN:
1468-201X
ISSN:
1355-6037
URN:
uuid:9afb6e1b-5ff1-4b03-a025-9fb04fb4fbec
Source identifiers:
104967
Local pid:
pubs:104967

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