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Thesis

Role of the chromatin remodeler ATRX in the regulation of gene expression

Abstract:

The ATR-X syndrome is an inherited, X-linked condition associated with alpha-thalassaemia and a variety of developmental abnormalities including profound intellectual disabilities. It results from mutations in a chromatin remodeling factor (called ATRX) which has been shown to perturb a wide range of nuclear activities including replication, transcription and DNA methylation. Although ATRX is known to play a role in the turnover of the histone variant H3.3, the precise role of ATRX in...

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Department:
NDCLS
Role:
Author

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Department:
NDCLS
Role:
Supervisor
Department:
NDCLS/WIMM
Role:
Supervisor
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Grant:
4 Year MRC WIMM Prize PhD Studentships
Funding agency for:
Julia Truch
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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