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Autophagy Controls Acquisition of Aging Features in Macrophages.

Abstract:

Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages and other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as 'inflamm-aging'. It is presently unclear how healthy macrophages are maintained throughout life and what connects inflammation with myeloid dysfunction during aging. Autophagy, an intracellular degradation mechanism, has known links with aging and lifespan extension. Here...

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Publication status:
Published
Peer review status:
Peer Reviewed

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Publisher copy:
10.1159/000370112

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Mortensen, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
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Nuffield Department of Medicine More from this funder
Wellcome Trust More from this funder
MRC Human Immunology Unit, Oxford. More from this funder
Publisher:
S. Karger AG Publisher's website
Journal:
Journal of Innate Immunity Journal website
Publication date:
2015-03-05
DOI:
EISSN:
1662-8128
ISSN:
1662-811X
URN:
uuid:9aeeb624-e44d-42c9-9e61-c23e4baffc31
Source identifiers:
512580
Local pid:
pubs:512580
Language:
English

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