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Journal article

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

Abstract:

The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF) transcriptional complex. HIF activity is deregulated in many human cancers, especially those that are highly hypoxic. Hypoxic tumour cells are usually resistant to radiotherapy and most conventional chemotherapeutic agents, rendering them highly aggressive and metastatic. Overexpression of HIF-alpha, the regulatory subunit of HIF, is associated with increased vascular density, severity of tumour grade, ...

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Publication status:
Published

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Publisher copy:
10.1017/s1462399409001173

Authors


Journal:
Expert reviews in molecular medicine
Volume:
11
Pages:
e26
Publication date:
2009-01-01
DOI:
EISSN:
1462-3994
ISSN:
1462-3994
URN:
uuid:9aeabe21-2ff9-4753-a356-7111f78130b2
Source identifiers:
316121
Local pid:
pubs:316121

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