- Abstract:
-
The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF) transcriptional complex. HIF activity is deregulated in many human cancers, especially those that are highly hypoxic. Hypoxic tumour cells are usually resistant to radiotherapy and most conventional chemotherapeutic agents, rendering them highly aggressive and metastatic. Overexpression of HIF-alpha, the regulatory subunit of HIF, is associated with increased vascular density, severity of tumour grade, ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1017/s1462399409001173
-
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- Journal:
- Expert reviews in molecular medicine
- Volume:
- 11
- Pages:
- e26
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1462-3994
- ISSN:
-
1462-3994
- URN:
-
uuid:9aeabe21-2ff9-4753-a356-7111f78130b2
- Source identifiers:
-
316121
- Local pid:
- pubs:316121
- Copyright date:
- 2009
Journal article
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
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