Journal article icon

Journal article

In vivo pretargeted imaging of HER2 and TAG-72 expression using the HaloTag enzyme

Abstract:

A novel pretargeted SPECT imaging strategy based on the HaloTag enzyme has been evaluated for the first time in a living system. To determine the efficacy of this approach, two clinically relevant cancer biomarkers, HER2 and TAG-72, were selected to represent models of internalizing and non-internalizing antigens, respectively. In MDA-MB-231/H2N (HER2-expressing) and LS174T (TAG-72-expressing) xenograft tumors in mice, pretargeting experiments were performed in which HaloTag-conjugated deriva...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.molpharmaceut.7b00172

Authors


More by this author
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Expand authors...
More from this funder
Grant:
*Grant Number Example*
Publisher:
American Chemical Society Publisher's website
Journal:
Molecular Pharmaceutics Journal website
Volume:
14
Issue:
7
Pages:
2307-2313
Publication date:
2017-05-15
Acceptance date:
2017-05-15
DOI:
EISSN:
1543-8392
ISSN:
1543-8384
Pubs id:
pubs:695667
URN:
uri:9ae6d9f2-c2e1-4218-8e60-301c76a84b32
UUID:
uuid:9ae6d9f2-c2e1-4218-8e60-301c76a84b32
Local pid:
pubs:695667

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP