Journal article
In vivo pretargeted imaging of HER2 and TAG-72 expression using the HaloTag enzyme
- Abstract:
-
A novel pretargeted SPECT imaging strategy based on the HaloTag enzyme has been evaluated for the first time in a living system. To determine the efficacy of this approach, two clinically relevant cancer biomarkers, HER2 and TAG-72, were selected to represent models of internalizing and non-internalizing antigens, respectively. In MDA-MB-231/H2N (HER2-expressing) and LS174T (TAG-72-expressing) xenograft tumors in mice, pretargeting experiments were performed in which HaloTag-conjugated deriva...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.6MB)
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- Publisher copy:
- 10.1021/acs.molpharmaceut.7b00172
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Authors
Funding
Cancer Research UK
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Molecular Pharmaceutics Journal website
- Volume:
- 14
- Issue:
- 7
- Pages:
- 2307-2313
- Publication date:
- 2017-05-15
- Acceptance date:
- 2017-05-15
- DOI:
- EISSN:
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1543-8392
- ISSN:
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1543-8384
Item Description
- Pubs id:
-
pubs:695667
- UUID:
-
uuid:9ae6d9f2-c2e1-4218-8e60-301c76a84b32
- Local pid:
- pubs:695667
- Deposit date:
- 2017-05-18
Terms of use
- Copyright holder:
- © 2017 American Chemical Society
- Copyright date:
- 2017
- Notes:
- This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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