- Abstract:
-
The recently discovered human DNA polymerase lambda (DNA pol lambda) has been implicated in translesion DNA synthesis across abasic sites. One remarkable feature of this enzyme is its preference for Mn(2+) over Mg(2+) as the activating metal ion, but the molecular basis for this preference is not known. Here, we present a kinetic and thermodynamic analysis of the DNA polymerase reaction catalyzed by full length human DNA pol lambda, showing that Mn(2+) favors specifically the catalytic step o...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi034198m
-
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- Journal:
- Biochemistry
- Volume:
- 42
- Issue:
- 24
- Pages:
- 7467-7476
- Publication date:
- 2003-06-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:9adfce53-ec93-4112-a42b-fb65f27c751c
- Source identifiers:
-
417383
- Local pid:
- pubs:417383
- Copyright date:
- 2003
Journal article
Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.
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