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Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu.

Abstract:

It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (Abeta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. T...

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Authors


Inestrosa, NC More by this author
Chacón, MA More by this author
Villalón, A More by this author
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Journal:
Neurobiology of aging
Volume:
26
Issue:
7
Pages:
1023-1028
Publication date:
2005-07-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:9adee179-f166-4f5a-b2f0-c078d77443c9
Source identifiers:
425166
Local pid:
pubs:425166

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