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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Abstract:

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10(-8) to P = 10(-190)). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, includi...

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Publication status:
Published online

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Publisher copy:
10.1038/ng.970

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Journal:
Nature genetics
Volume:
43
Issue:
11
Pages:
1131-1138
Publication date:
2011-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:9ad58a3d-0c18-412e-9ac9-97c96afe171c
Source identifiers:
193321
Local pid:
pubs:193321

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