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Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease.

Abstract:

RATIONALE: Previous studies have demonstrated reductions of serotonin 5-HT 2A receptors in the neocortex of Alzheimer's disease (AD) patients. However, it is unclear whether such losses play a role in the cognitive decline of AD. OBJECTIVES: To correlate neocortical 5-HT 2A receptor alterations with cognitive decline in AD. METHODS: Postmortem frontal and temporal cortical 5-HT 2A receptors were measured by [3H]ketanserin binding in aged controls as well as in a cohort of AD patients who had ...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-004-2077-2

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Journal:
Psychopharmacology
Volume:
179
Issue:
3
Pages:
673-677
Publication date:
2005-05-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:9ad0e7d8-a923-4778-b671-7cc28126c497
Source identifiers:
180222
Local pid:
pubs:180222

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