- Abstract:
-
RATIONALE: Previous studies have demonstrated reductions of serotonin 5-HT 2A receptors in the neocortex of Alzheimer's disease (AD) patients. However, it is unclear whether such losses play a role in the cognitive decline of AD. OBJECTIVES: To correlate neocortical 5-HT 2A receptor alterations with cognitive decline in AD. METHODS: Postmortem frontal and temporal cortical 5-HT 2A receptors were measured by [3H]ketanserin binding in aged controls as well as in a cohort of AD patients who had ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00213-004-2077-2
-
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- Journal:
- Psychopharmacology
- Volume:
- 179
- Issue:
- 3
- Pages:
- 673-677
- Publication date:
- 2005-05-05
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:9ad0e7d8-a923-4778-b671-7cc28126c497
- Source identifiers:
-
180222
- Local pid:
- pubs:180222
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease.
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