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Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse

Abstract:

It has been well established that maternal inflammation during pregnancy alters neurological function in the offspring, but its impact on cortical development and long-term consequences on the cytoarchitecture is largely unstudied. Here we report that lipopolysaccharide-induced systemic maternal inflammation in C57Bl/6 mice at embryonic Day 13.5 of pregnancy, as early as 8h after challenge, caused a significant reduction in cell proliferation in the ventricular zone of the developing cerebral...

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Publisher copy:
10.1093/brain/awr237

Authors


Turnquist, C More by this author
Dziegielewska, KM More by this author
Saunders, NR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
Brain
Volume:
134
Issue:
11
Pages:
3236-3248
Publication date:
2011-11-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:9acdffdf-ed5c-4ecf-84f3-0fcc31064898
Source identifiers:
206452
Local pid:
pubs:206452

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