- Abstract:
-
Mutations in Bruton's tyrosine kinase (Btk) cause the B-cell disorder X-linked agammaglobulinaemia (XLA) in humans, but the effect of Btk deficiency in human bone health has not been investigated previously. In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. Contrary to expectation, XLA patients did not exhibit increased bone density or alterations in serum markers of bone turno...
Expand abstract - Publisher copy:
- 10.1002/jbmr.210
-
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- Journal:
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Volume:
- 26
- Issue:
- 1
- Pages:
- 182-192
- Publication date:
- 2011-01-05
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- URN:
-
uuid:9acb3555-5be4-41a9-8b42-df6169710843
- Source identifiers:
-
223535
- Local pid:
- pubs:223535
- Copyright date:
- 2011
Journal article
Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.
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