Journal article icon

Journal article

Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.

Abstract:

Mutations in Bruton's tyrosine kinase (Btk) cause the B-cell disorder X-linked agammaglobulinaemia (XLA) in humans, but the effect of Btk deficiency in human bone health has not been investigated previously. In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. Contrary to expectation, XLA patients did not exhibit increased bone density or alterations in serum markers of bone turno...

Expand abstract

Actions


Access Document


Publisher copy:
10.1002/jbmr.210

Authors


Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
26
Issue:
1
Pages:
182-192
Publication date:
2011-01-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:9acb3555-5be4-41a9-8b42-df6169710843
Source identifiers:
223535
Local pid:
pubs:223535

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP