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Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors.

Abstract:

We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT2 receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP...

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Publication status:
Published

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Publisher copy:
10.1007/s002130050747

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Journal:
Psychopharmacology
Volume:
140
Issue:
1
Pages:
120-122
Publication date:
1998-11-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:9abb9822-8481-49a9-ad1e-9ff2860df021
Source identifiers:
185877
Local pid:
pubs:185877

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