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Structures of Ebola virus glycoprotein complexes with tricyclic antidepressant and antipsychotic drugs

Abstract:

A large number of Food and Drug Administration (FDA)-approved drugs have been found to inhibit the cell entry of Ebola virus (EBOV). However, since these drugs have various primary pharmacological targets, their mechanisms of action against EBOV remain largely unknown. We have previously shown that six FDA-approved drugs inhibit EBOV infection by interacting with and destabilizing the viral glycoprotein (GP). Here we show that antidepressants imipramine and clomipramine and antipsychotic drug...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.jmedchem.8b00350

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Structural Biology
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Human Genetics Wt Centre
ORCID:
0000-0003-4015-1404
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Structural Biology
Townsend, AR More by this author
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Funding agency for:
Ren, J
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Medicinal Chemistry Journal website
Volume:
61
Issue:
11
Pages:
4938-4945
Publication date:
2018-05-09
Acceptance date:
2018-05-09
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Pubs id:
pubs:853666
URN:
uri:9aa785c0-5ac3-4806-8556-6952f9e0cbd5
UUID:
uuid:9aa785c0-5ac3-4806-8556-6952f9e0cbd5
Local pid:
pubs:853666
Language:
English

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