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Journal article

Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.

Abstract:

SIRPalpha is an inhibitory receptor present on myeloid cells that interacts with a widely distributed membrane protein CD47. The activating member SIRPbeta, despite extensive sequence similarity to SIRPalpha in the extracellular region, shows negligible binding to CD47. The SIRPalpha/CD47 interaction is unusual in that it can lead to bidirectional signalling through both SIRPalpha and CD47. This review concentrates on the interactions of SIRPalpha with CD47 where recent data have shed light o...

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Publisher copy:
10.1016/j.coi.2009.01.008

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Current opinion in immunology
Volume:
21
Issue:
1
Pages:
47-52
Publication date:
2009-02-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:9aa7464c-fc91-4144-893d-c16d2d241f59
Source identifiers:
223846
Local pid:
pubs:223846

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