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Journal article

Chemokine antagonism in chronic hepatitis C virus infection.

Abstract:

Immune responses to hepatitis C virus (HCV) fail to clear the virus in most individuals. Why patients who are less likely to clear HCV infection have high plasma levels of CXCL10 (also known as IP-10), a chemokine that directs T cells to sites of infection, has long been unclear. In this issue of the JCI, Casrouge and colleagues shed light on this paradox by showing that CXCL10 in the plasma of many HCV patients is enzymatically processed to produce a CXCL10 receptor antagonist. These finding...

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Publisher copy:
10.1172/jci45610

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of clinical investigation
Volume:
121
Issue:
1
Pages:
25-27
Publication date:
2011-01-29
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:9a8dc7b8-6f86-4e8b-a658-17ab971f0e41
Source identifiers:
426221
Local pid:
pubs:426221

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