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Human hypoxic pulmonary vasoconstriction is unaltered by 8 h of preceding isocapnic hyperoxia

Abstract:

Exposure to sustained hypoxia of 8 h duration increases the sensitivity of the pulmonary vasculature to acute hypoxia, but it is not known whether exposure to sustained hyperoxia affects human pulmonary vascular control. We hypothesized that exposure to 8 h of hyperoxia would diminish the hypoxic pulmonary vasoconstriction (HPV) that occurs in response to a brief exposure to hypoxia. Eleven healthy volunteers were studied in a crossover protocol with randomization of order. Each volunteer was...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.14814/phy2.13396

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy & Genetics
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Physiological Reports Journal website
Volume:
5
Issue:
17
Pages:
e13396
Publication date:
2017-09-12
Acceptance date:
2017-07-31
DOI:
EISSN:
2051-817X
Pubs id:
pubs:710868
URN:
uri:9a8ca6bd-c2fc-4715-96cd-180943741a52
UUID:
uuid:9a8ca6bd-c2fc-4715-96cd-180943741a52
Local pid:
pubs:710868
Paper number:
17

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