Response of the splenic dendritic cell population to malaria infection.

Journal article

Dendritic cells, particularly those residing in the spleen, are thought to orchestrate acquired immunity to malaria, but it is not known how the splenic dendritic cell population responds to malaria infection and how this response compares with the responses of other antigen-presenting cells. We investigated this question for Plasmodium chabaudi AS infection in C57BL/6 mice. We found that dendritic cells, defined here by the CD11c marker, migrated from the marginal zone of the spleen into the...

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Authors: Leisewitz, A; Rockett, K; Gumede, B; Jones, M; Urban, B

• Publication status: Published
• Journal: Infection and immunity
• Volume: 72
• Issue: 7
• Pages: 4233-4239
• Publication date: 2004-07-01
• DOI: 10.1128/iai.72.7.4233-4239.2004
• EISSN: 1098-5522
• ISSN: 0019-9567
• Language: English
• Keywords: Antigen-Presenting Cells; Mice, Inbred C57BL; Interferon-gamma; Female; Dendritic Cells; Spleen; Plasmodium chabaudi; Animals; Antigens, CD11; Mice; Malaria