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Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes.

Abstract:

We have compared the induction of apoptosis and cytokine release by UVB and gamma-radiation in primary (untransformed) and in two immortalized human epithelial/keratinocyte cell lines, HaCaT and KB (KB is now known to be a subline of the ubiquitous keratin-forming tumour cell line HeLa and we therefore designate it HeLa-KB). In both the primary and the immortalized cell lines apoptosis and release of the inflammatory cytokine interleukin-6 are induced rapidly following UVB irradiation. In con...

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Publication status:
Published

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Publisher copy:
10.1093/carcin/21.6.1087

Authors


Petit-Frère, C More by this author
Capulas, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Carcinogenesis
Volume:
21
Issue:
6
Pages:
1087-1095
Publication date:
2000-06-05
DOI:
EISSN:
1460-2180
ISSN:
0143-3334
URN:
uuid:9a867f81-c485-4ca2-ba48-d9fa024f3395
Source identifiers:
30064
Local pid:
pubs:30064

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