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Mass spectrometry of macromolecular assemblies: preservation and dissociation

Abstract:
Mass spectrometry not only plays a crucial role in the identification of proteins involved in the intricate interaction networks of the cell, but also is increasingly involved in the characterization of the non-covalent complexes formed by interacting partners. Recent developments have enabled the use of gas phase dissociation to probe oligomeric organization and topology, and increased understanding of the electrospray process is leading to knowledge of the structure of protein assemblies both in solution and in the gas phase.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.sbi.2006.03.009

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Institution:
University of Oxford
Oxford college:
University College
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Exeter College
Role:
Author
Publisher:
Elsevier
Journal:
Current opinion in structural biology More from this journal
Volume:
16
Issue:
2
Pages:
245-251
Publication date:
2006-04-01
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Pmid:
16563743
Language:
English
Keywords:
Pubs id:
pubs:59288
UUID:
uuid:9a7ccb23-7042-4b69-a6cb-72308515361b
Local pid:
pubs:59288
Source identifiers:
59288
Deposit date:
2017-01-25

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