- Abstract:
-
Studies in rat aorta have shown that the Na-K-2Cl cotransporter NKCC1 is activated by vasoconstrictors and inhibited by nitrovasodilators, contributes to smooth muscle tone in vitro, and is upregulated in hypertension. To determine the role of NKCC1 in systemic vascular resistance and hypertension, blood pressure was measured in rats before and after inhibition of NKCC1 with bumetanide. Intravenous infusion of bumetanide sufficient to yield a free plasma concentration above the IC(50) for NKC...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/ajpheart.01402.2006
-
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- Journal:
- American journal of physiology. Heart and circulatory physiology
- Volume:
- 292
- Issue:
- 5
- Pages:
- H2100-H2105
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- URN:
-
uuid:9a6ff46e-f51c-4eca-a979-6a4dc46cc114
- Source identifiers:
-
106154
- Local pid:
- pubs:106154
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.
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