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Journal article

Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.

Abstract:

Studies in rat aorta have shown that the Na-K-2Cl cotransporter NKCC1 is activated by vasoconstrictors and inhibited by nitrovasodilators, contributes to smooth muscle tone in vitro, and is upregulated in hypertension. To determine the role of NKCC1 in systemic vascular resistance and hypertension, blood pressure was measured in rats before and after inhibition of NKCC1 with bumetanide. Intravenous infusion of bumetanide sufficient to yield a free plasma concentration above the IC(50) for NKC...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01402.2006

Authors


Martin, CF More by this author
Gordon, FJ More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
292
Issue:
5
Pages:
H2100-H2105
Publication date:
2007-05-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:9a6ff46e-f51c-4eca-a979-6a4dc46cc114
Source identifiers:
106154
Local pid:
pubs:106154

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