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Dopamine-mediated reinforcement learning signals in the striatum and ventromedial prefrontal cortex underlie value-based choices.

Abstract:

A large body of evidence exists on the role of dopamine in reinforcement learning. Less is known about how dopamine shapes the relative impact of positive and negative outcomes to guide value-based choices. We combined administration of the dopamine D(2) receptor antagonist amisulpride with functional magnetic resonance imaging in healthy human volunteers. Amisulpride did not affect initial reinforcement learning. However, in a later transfer phase that involved novel choice situations requir...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
31
Issue:
5
Pages:
1606-1613
Publication date:
2011-02-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:9a6d9c4b-83e5-43de-a69b-e44ec7b89010
Source identifiers:
241719
Local pid:
pubs:241719

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