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Thesis

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1

Abstract:

Apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair factor involved in the DNA base excision repair (BER) pathway that is required for the maintenance of genome stability. In this pathway, APE1 cleaves DNA at an abasic site to generate a DNA single strand break, allowing for repair completion by a DNA polymerase and a DNA ligase. High levels of APE1 have been observed in multiple cancer types however it is not understood if this contributes to cancer onset and development. What...

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Contributors

Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Dr Grigory Dianov: Biochemistry Group
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
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Funding agency for:
Cornelia Meisenberg
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Funding agency for:
Cornelia Meisenberg
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:9a6582d4-6fc0-48c9-9c13-6c99e23e66e9
Local pid:
ora:8368

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