Antigenic reactivity of peptides derived from wheat gluten with sera from patients with coeliac disease.

Journal article

Fraction B from a peptic-tryptic digest of gluten from Scout 66 wheat has already been shown to cause histological damage to the jejunal mucosa of coeliac patients. Peptide fractions, designated P1-P4, have been prepared from it by a combination of gel filtration (producing an intermediate fraction pseudo-B2: psi B2) and reverse-phase high pressure liquid chromatography. An enzyme-linked immunosorbent assay (ELISA) has been used to measure IgG antibodies to fraction B in sera from untreated c...

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Authors: Rawcliffe, P; Priddle, J; Jewell, D

• Publication status: Published
• Journal: Clinical science (London, England : 1979)
• Volume: 69
• Issue: 1
• Pages: 97-104
• Publication date: 1985-07-01
• EISSN: 1470-8736
• ISSN: 0143-5221
• Language: English
• Keywords: Humans; Enzyme-Linked Immunosorbent Assay; Chromatography, High Pressure Liquid; Triticum; Chromatography, Gel; Crohn Disease; Peptide Fragments; Antigen-Antibody Reactions; Immunoglobulin G; Colitis, Ulcerative; Celiac Disease; Glutens