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Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants.

Abstract:

Using a large panel of human immunodeficiency virus type 1 site-directed mutants, we have observed a higher correlation than has previously been demonstrated between zidovudine (AZT)-triphosphate resistance data at the reverse transcriptase (RT) level and corresponding viral AZT resistance. This enhanced-resistance effect at the RT level was seen with ATP and to a lesser extent with PP(i) when ATP was added at physiological concentrations. The ATP-dependent mechanism (analogous to pyrophospho...

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Publication status:
Published

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Authors


Lennerstrand, J More by this author
Hertogs, K More by this author
Stammers, DK More by this author
Larder, BA More by this author
Journal:
Journal of virology
Volume:
75
Issue:
15
Pages:
7202-7205
Publication date:
2001-08-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:9a40611b-c381-45e6-9def-cd5250fb15c6
Source identifiers:
72605
Local pid:
pubs:72605

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