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Journal article

Alternative splicing of the NMDAR1 subunit affects modulation by calcium.

Abstract:

Four splice variants of the NR1 receptor subunit, characterized by the presence or absence of cassettes encoding inserts of 21 (Insert 1) and 37 (Insert 2) amino acids were expressed in Xenopus oocytes and studied using voltage-clamp techniques. In 1.8 mM Ca2+, a slow inward current (Islow), which peaked 20 s after exposure to NMDA was evident when Insert I was present, but not when absent. However, in elevated external Ca2+ medium a similar Islow was observed in variants missing Insert I. Th...

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Publication status:
Published

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Journal:
Brain research. Molecular brain research
Volume:
39
Issue:
1-2
Pages:
99-108
Publication date:
1996-07-05
DOI:
ISSN:
0169-328X
URN:
uuid:9a23de38-38ac-41f1-983c-1229f366a5f7
Source identifiers:
52289
Local pid:
pubs:52289

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