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Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex

Abstract:

The cannabinoid CB1 receptor has gained much attention as a potential pharmacotherapeutic target in various neurodegenerative diseases including Alzheimer's disease (AD). However, the relation of CB1 receptors to cognitive function in AD is at present unclear. In this study, postmortem brain tissues from a cohort of prospectively assessed, neuropathologically confirmed AD patients and aged controls were used to measure CB1 receptors by immunoblotting, and a subset of subjects also had [ 3H]SR...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Neurochemistry International
Volume:
57
Issue:
8
Pages:
985-989
Publication date:
2010-12-05
DOI:
ISSN:
0197-0186
URN:
uuid:9a1ede18-fde0-42ad-90c2-ac772e1fec39
Source identifiers:
107168
Local pid:
pubs:107168

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