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Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents.

Abstract:

Among matrix metalloproteinases (MMPs), the subfamily of gelatinases (MMP-2, MMP-9) is of particular interest due to their ability to degrade type IV collagen and other non-fibrillar collagen domains and proteins such as fibronectin and laminin. Whilst malignant cells often over-express various MMPs, the gelatinases have been most consistently detected in malignant tissues and associated with tumor growth, metastatic potential and angiogenesis. Radiosynthesis of carboxylic (1') and hydroxamic...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Volume:
64
Issue:
6
Pages:
677-685
Publication date:
2006-06-01
DOI:
EISSN:
1872-9800
ISSN:
0969-8043
Source identifiers:
271408

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