Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents.

Journal article

Among matrix metalloproteinases (MMPs), the subfamily of gelatinases (MMP-2, MMP-9) is of particular interest due to their ability to degrade type IV collagen and other non-fibrillar collagen domains and proteins such as fibronectin and laminin. Whilst malignant cells often over-express various MMPs, the gelatinases have been most consistently detected in malignant tissues and associated with tumor growth, metastatic potential and angiogenesis. Radiosynthesis of carboxylic (1') and hydroxamic...

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Authors: Oltenfreiter, R; Staelens, L; Kersemans, V; Cornelissen, B; Frankenne, F

• Publication status: Published
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
• Volume: 64
• Issue: 6
• Pages: 677-685
• Publication date: 2006-06-01
• DOI: 10.1016/j.apradiso.2006.01.016
• EISSN: 1872-9800
• ISSN: 0969-8043
• Language: English
• Keywords: Valine; Biphenyl Compounds; Sulfonamides; Organ Specificity; Radiopharmaceuticals; Mice; Serum Albumin; Male; Matrix Metalloproteinase Inhibitors; Animals; Neoplasms, Experimental; Mice, Nude; Iodine Radioisotopes; Tomography, Emission-Computed, Single-Photon; Butyrates