Journal article
Amphioxus functional genomics and the origins of vertebrate gene regulation
- Abstract:
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Vertebrates have greatly elaborated the basic chordate bodyplan and evolved highly distinctive genomes, sculpted by two whole genome duplications (WGD). To investigate the evolution of genome regulation in chordates, we characterized promoters, DNA methylation, chromatin accessibility, histone modifications and transcriptomes in multiple tissues and throughout development of amphioxus. This revealed an intermediate stage in the evolution of differentially methylated regulatory elements, and h...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 28.3MB)
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- Publisher copy:
- 10.1038/s41586-018-0734-6
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Authors
Funding
+ European Commission
More from this funder
Funding agency for:
Holland, P
Grant:
FP7/2007-2013-ERC-268513
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 564
- Pages:
- 64–70
- Publication date:
- 2018-11-21
- Acceptance date:
- 2018-10-18
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Source identifiers:
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930103
Item Description
- Pubs id:
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pubs:930103
- UUID:
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uuid:9a053aec-3e96-4674-99a8-c07a6b394c2a
- Local pid:
- pubs:930103
- Deposit date:
- 2018-10-22
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2018
- Notes:
- © 2018 Springer Nature Limited. All rights reserved. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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