Journal article icon

Journal article

Amphioxus functional genomics and the origins of vertebrate gene regulation

Abstract:

Vertebrates have greatly elaborated the basic chordate bodyplan and evolved highly distinctive genomes, sculpted by two whole genome duplications (WGD). To investigate the evolution of genome regulation in chordates, we characterized promoters, DNA methylation, chromatin accessibility, histone modifications and transcriptomes in multiple tissues and throughout development of amphioxus. This revealed an intermediate stage in the evolution of differentially methylated regulatory elements, and h...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-018-0734-6

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Holland, P
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
564
Pages:
64–70
Publication date:
2018-11-21
Acceptance date:
2018-10-18
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:930103
URN:
uri:9a053aec-3e96-4674-99a8-c07a6b394c2a
UUID:
uuid:9a053aec-3e96-4674-99a8-c07a6b394c2a
Local pid:
pubs:930103

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP