Establishment of a gastrointestinal epithelial organoid assay to assess bowel toxicity in response to chemoradiation treatment

Thesis

Introduction

Chemoradiation is the most common non-surgical treatment for MIBC. However, chemoradiation is associated with acute and late intestinal toxicity, as irradiation (IR) of the surrounding small bowel and rectum is virtually inevitable. In the search for new, less toxic radiosensitisers, it is important to have an assay to determine normal intestinal toxicity. To meet this need, we have investigated whether gastrointestinal toxicity can be predicted ex vivo through the ... Expand abstract

Authors: Price, G

• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English