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Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones

Abstract:
The electrophilic amination of a β-aminolactam, itself derived from the conjugate addition of O,N-dibenzyl-hydroxylamine to a highly activated α, β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.
Publication status:
Published

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Publisher copy:
10.1039/b106783b

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 More from this journal
Issue:
22
Pages:
3007-3012
Publication date:
2001-01-01
DOI:
EISSN:
1364-5463
ISSN:
1472-7781


Language:
English
Pubs id:
pubs:38045
UUID:
uuid:99f1c325-006b-4b12-8ac9-aaff4d2250f0
Local pid:
pubs:38045
Source identifiers:
38045
Deposit date:
2012-12-19

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