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Combined inhibition of mTORC1 and mTORC2 signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: in vitro and in vivo studies in female athymic nude mice.

Abstract:

Several lines of evidence, including the recent discovery of novel susceptibility genes, point out an important role for the mammalian target of rapamycin (mTOR) signaling pathway in the development of pheochromocytoma. Analyzing a set of pheochromocytomas from patients with different genetic backgrounds, we observed and confirmed a significant overexpression of key mTOR complex (mTORC) signaling mediators. Using selective ATP-competitive inhibitors targeting both mTORC1 and mTORC2, we signif...

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Publication status:
Published

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Publisher copy:
10.1210/en.2012-1854

Authors


Giubellino, A More by this author
Bullova, P More by this author
Nölting, S More by this author
Turkova, H More by this author
Powers, JF More by this author
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Journal:
Endocrinology
Volume:
154
Issue:
2
Pages:
646-655
Publication date:
2013-02-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:99ec4425-afd1-4269-99dc-dadc37feb0b7
Source identifiers:
374268
Local pid:
pubs:374268

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