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Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle

Abstract:

DNA translesion synthesis (TLS) is a crucial damage tolerance pathway that oversees the completion of DNA replication in the presence of DNA damage. TLS polymerases are capable of bypassing a distorted template but they are generally considered inaccurate and they need to be tightly regulated. We have previously shown that polη is phosphorylated on Serine 601 after DNA damage and we have demonstrated that this modification is important for efficient damage bypass. Here we report that polη is ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkx619

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Grant:
PCIG10-GA-2011-303806 to S.S.
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Grant:
UF150651, RG160363 to M.A.C.
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Grant:
153/092 to M.A.C.
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
16
Pages:
9441–9454
Publication date:
2017-07-24
Acceptance date:
2017-07-06
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:703074
URN:
uri:99eb66f8-6e83-40e3-a754-6d59312c8883
UUID:
uuid:99eb66f8-6e83-40e3-a754-6d59312c8883
Local pid:
pubs:703074
Paper number:
16

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