Journal article
Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle
- Abstract:
-
DNA translesion synthesis (TLS) is a crucial damage tolerance pathway that oversees the completion of DNA replication in the presence of DNA damage. TLS polymerases are capable of bypassing a distorted template but they are generally considered inaccurate and they need to be tightly regulated. We have previously shown that polη is phosphorylated on Serine 601 after DNA damage and we have demonstrated that this modification is important for efficient damage bypass. Here we report that polη is ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 5.4MB)
-
- Publisher copy:
- 10.1093/nar/gkx619
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Associazione Italiana per la Ricerca sul Cancro
More from this funder
Grant:
Start-up Grant
12710 to S.S
Expand funders...
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 16
- Pages:
- 9441–9454
- Publication date:
- 2017-07-24
- Acceptance date:
- 2017-07-06
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- Source identifiers:
-
703074
Item Description
- Keywords:
- Pubs id:
-
pubs:703074
- UUID:
-
uuid:99eb66f8-6e83-40e3-a754-6d59312c8883
- Local pid:
- pubs:703074
- Deposit date:
- 2017-07-06
Terms of use
- Copyright holder:
- Bertoletti et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which
permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited
If you are the owner of this record, you can report an update to it here: Report update to this record