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Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia

Abstract:

Background: Advanced glycation end-products (AGEs) and their receptor (RAGE) occur in dementia of the Alzheimer's type and diabetic microvascular disease. Accumulation of AGEs relates to risk factors for vascular dementia with ageing, including hypertension and diabetes. Cognitive dysfunction in vascular dementia may relate to microvascular disease resembling that in diabetes. We tested if, among people with cerebrovascular disease, (1) those with dementia have higher levels of neuronal and v...

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Publication status:
Published

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Publisher copy:
10.1186/1471-2377-7-35

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
BMC NEUROLOGY
Volume:
7
Issue:
1
Pages:
35-35
Publication date:
2007-10-16
DOI:
EISSN:
1471-2377
ISSN:
1471-2377
URN:
uuid:99e1747a-21b3-4ed2-ba55-e403061216ae
Source identifiers:
243178
Local pid:
pubs:243178
Language:
English

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