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Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia

Abstract:

Background: Advanced glycation end-products (AGEs) and their receptor (RAGE) occur in dementia of the Alzheimer's type and diabetic microvascular disease. Accumulation of AGEs relates to risk factors for vascular dementia with ageing, including hypertension and diabetes. Cognitive dysfunction in vascular dementia may relate to microvascular disease resembling that in diabetes. We tested if, among people with cerebrovascular disease, (1) those with dementia have higher levels of neuronal and v...

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Publication status:
Published

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Publisher copy:
10.1186/1471-2377-7-35

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
BMC NEUROLOGY
Volume:
7
Issue:
1
Pages:
35-35
Publication date:
2007-10-16
DOI:
EISSN:
1471-2377
ISSN:
1471-2377
Source identifiers:
243178
Language:
English
Pubs id:
pubs:243178
UUID:
uuid:99e1747a-21b3-4ed2-ba55-e403061216ae
Local pid:
pubs:243178
Deposit date:
2012-12-19

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