Photophysical properties and intracellular imaging of water-soluble porphyrin dimers for two-photon excited photodynamic therapy.

Journal article

We have investigated the photophysical properties and intracellular behaviour of a series of hydrophilic conjugated porphyrin dimers. All the dimers exhibit intense linear absorption at 650-800 nm and high singlet oxygen quantum yields (0.5-0.9 in methanol), as required for an efficient sensitiser for photodynamic therapy (PDT). They also exhibit fluorescence at 700-800 nm, with fluorescence quantum yields of up to 0.13 in methanol, and show extremely large two-photon absorption maxima of 8,0...

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Authors: Kuimova, M; Collins, H; Balaz, M; Dahlstedt, E; Levitt, J

• Publication status: Published
• Journal: Organic and biomolecular chemistry
• Volume: 7
• Issue: 5
• Pages: 889-896
• Publication date: 2009-03-01
• DOI: 10.1039/b814791d
• EISSN: 1477-0539
• ISSN: 1477-0520
• Language: English
• Keywords: Cells, Cultured; Photochemotherapy; Porphyrins; Infrared Rays; Photosensitizing Agents; Solubility; Humans; Photons; Animals; Cells; Dimerization