Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease.

Journal article

Intrastriatal transplantation of foetal midbrain dopamine (DA) neurons ameliorates the fundamental symptoms of dopaminergic denervation in clinical and experimental parkinsonism despite providing only restricted reinnervation. To understand how DA function is restored by these grafts we used fast-scan cyclic voltammetry at a carbon-fiber microelectrode in vitro to monitor directly and in "real time" the dynamics of graft-derived DA. Simulations of Michaelis-Menten kinetics were used to model ...

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Authors: Cragg, S; Clarke, D; Greenfield, S

• Publication status: Published
• Journal: Experimental neurology
• Volume: 164
• Issue: 1
• Pages: 145-153
• Publication date: 2000-07-01
• DOI: 10.1006/exnr.2000.7420
• EISSN: 1090-2430
• ISSN: 0014-4886
• Language: English
• Keywords: Rats, Wistar; Parkinson Disease, Secondary; Oxidopamine; Female; Kinetics; Electric Stimulation; Animals; Models, Neurological; Brain Tissue Transplantation; Piperazines; Corpus Striatum; Recovery of Function; Dopamine Uptake Inhibitors; Substantia Nigra; Dopamine; Rats; Extracellular Space; Neurons