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Journal article

Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease.

Abstract:

Intrastriatal transplantation of foetal midbrain dopamine (DA) neurons ameliorates the fundamental symptoms of dopaminergic denervation in clinical and experimental parkinsonism despite providing only restricted reinnervation. To understand how DA function is restored by these grafts we used fast-scan cyclic voltammetry at a carbon-fiber microelectrode in vitro to monitor directly and in "real time" the dynamics of graft-derived DA. Simulations of Michaelis-Menten kinetics were used to model ...

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Publication status:
Published

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Publisher copy:
10.1006/exnr.2000.7420

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Experimental neurology
Volume:
164
Issue:
1
Pages:
145-153
Publication date:
2000-07-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:99d4bf68-55f6-4e5a-86e1-52a68a53d544
Source identifiers:
97685
Local pid:
pubs:97685

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