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Prolonged exposure of naive CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length.

Abstract:

Interleukin (IL)-7 and IL-15 are cytokines implicated in homeostatic control of the peripheral CD8 T-cell pool. We compared the effects of IL-7 and IL-15 on survival and proliferation of purified human CD8+ T-cell subsets. Low concentrations of either cytokine reduced the spontaneous apoptosis of all subsets, and enhancement of survival corresponded to the extent of Bcl-2 up-regulation. Surprisingly, although minimal proliferation of naïve CD8+ T cells was observed during the first week of cu...

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Authors


Wallace, DL More by this author
Bérard, M More by this author
Soares, MV More by this author
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Journal:
Immunology
Volume:
119
Issue:
2
Pages:
243-253
Publication date:
2006-10-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:99c076df-3c41-4e98-addb-da2a025ac5d4
Source identifiers:
33614
Local pid:
pubs:33614

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