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High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.

Abstract:

Obesity frequently leads to the development of hypertension. We hypothesized that high-fat diet (HFD)-induced obesity impairs the endothelium-dependent dilation of arterioles. Male Wistar rats were fed with normal (control) or HFD (60% of saturated fat, for 10 wk). In rats with HFD, body weight, mean arterial blood pressure, and serum insulin, cholesterol, and glucose were elevated. In isolated gracilis muscle arterioles (diameter: approximately 160 microm) of HFD, rat dilations to ACh (at 1 ...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00389.2006

Authors


Pásztor, ET More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
291
Issue:
5
Pages:
H2107-H2115
Publication date:
2006-11-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:99bc9a9e-ee69-4159-9af0-072749da470f
Source identifiers:
164437
Local pid:
pubs:164437

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