- Abstract:
-
Obesity frequently leads to the development of hypertension. We hypothesized that high-fat diet (HFD)-induced obesity impairs the endothelium-dependent dilation of arterioles. Male Wistar rats were fed with normal (control) or HFD (60% of saturated fat, for 10 wk). In rats with HFD, body weight, mean arterial blood pressure, and serum insulin, cholesterol, and glucose were elevated. In isolated gracilis muscle arterioles (diameter: approximately 160 microm) of HFD, rat dilations to ACh (at 1 ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/ajpheart.00389.2006
-
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- Journal:
- American journal of physiology. Heart and circulatory physiology
- Volume:
- 291
- Issue:
- 5
- Pages:
- H2107-H2115
- Publication date:
- 2006-11-05
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- URN:
-
uuid:99bc9a9e-ee69-4159-9af0-072749da470f
- Source identifiers:
-
164437
- Local pid:
- pubs:164437
- Copyright date:
- 2006
Journal article
High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.
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