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The effect of diurnal variation, CYP2B6 genotype, and age on the pharmacokinetics of nevirapine in African Children

Abstract:

Objective

We aimed to characterise the effects of CYP2B6 polymorphisms, diurnal variation, and demographic factors on nevirapine pharmacokinetics in African children.

Methods

Nonlinear mixed-effects modelling conducted in NONMEM 7.3 described nevirapine plasma concentration-time data from 414 children aged 0.3–15 years.

Results

Nevirapine pharmacokinetics was best described using a 1-compartmental disposition model with elimination through a well-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1093/jac/dkw388

Authors


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Medical Research Council More from this funder
Department for International Development More from this funder
Ministerio de Sanidad y Consumo Spain More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Antimicrobial Chemotherapy Journal website
Volume:
72
Issue:
1
Pages:
190–199
Publication date:
2016-10-05
Acceptance date:
2016-08-18
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pubs id:
pubs:639002
URN:
uri:99a80c6d-5ee8-468f-b1d5-cf33b95fda37
UUID:
99a80c6d-5ee8-468f-b1d5-cf33b95fda37
Local pid:
pubs:639002

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