- Abstract:
-
Objective
We aimed to characterise the effects of CYP2B6 polymorphisms, diurnal variation, and demographic factors on nevirapine pharmacokinetics in African children.
Methods
Nonlinear mixed-effects modelling conducted in NONMEM 7.3 described nevirapine plasma concentration-time data from 414 children aged 0.3–15 years.
Results
Nevirapine pharmacokinetics was best described using a 1-compartmental disposition model with elimination through a well-...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 422.8KB)
-
- Publisher copy:
- 10.1093/jac/dkw388
-
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- Grant:
- 2004.01.H.d2.33011
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Antimicrobial Chemotherapy Journal website
- Volume:
- 72
- Issue:
- 1
- Pages:
- 190–199
- Publication date:
- 2016-10-05
- Acceptance date:
- 2016-08-18
- DOI:
- EISSN:
-
1460-2091
- ISSN:
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0305-7453
- Pubs id:
-
pubs:639002
- URN:
-
uri:99a80c6d-5ee8-468f-b1d5-cf33b95fda37
- UUID:
-
99a80c6d-5ee8-468f-b1d5-cf33b95fda37
- Local pid:
- pubs:639002
- Copyright holder:
- Walker et al
- Copyright date:
- 2016
- Notes:
- © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
The effect of diurnal variation, CYP2B6 genotype, and age on the pharmacokinetics of nevirapine in African Children
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Funding
+ European and Developing Countries Clinical Trials Partnership
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Medical Research Council
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Department for International Development
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Ministerio de Sanidad y Consumo Spain
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