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IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Abstract:

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global tran...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-08152-3

Authors


Nenseth, HZ More by this author
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ORCID:
0000-0002-3264-6039
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 323
Publication date:
2019-01-24
Acceptance date:
2018-12-07
DOI:
EISSN:
2041-1723
Pubs id:
pubs:966369
URN:
uri:999dfe25-8723-4cdb-9ee3-b93a35858521
UUID:
uuid:999dfe25-8723-4cdb-9ee3-b93a35858521
Local pid:
pubs:966369
Language:
English

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