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Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells.

Abstract:

All eukaryotic cells manifest cell cycle delay after exposure to DNA damaging agents. It has been proposed that such cell cycle checkpoints may allow DNA repair but direct evidence of such activity during the radiation-induced G2 delay has been lacking. We report here that cells arrested in G2 by radiation (2-3 Gy) and etoposide incorporate bromodeoxyuridine (BrdU) at discrete foci in the nucleus. We detected G2 cells with CENP-F, a nuclear protein maximally expressed in G2. Caffeine and okad...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1204445

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Oncogene
Volume:
20
Issue:
27
Pages:
3486-3496
Publication date:
2001-06-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:9986b537-0510-4898-bf7d-a5b3c164b268
Source identifiers:
118182
Local pid:
pubs:118182

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