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Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Abstract:

Polycyclic polyether natural products have fascinated chemists and biologists alike owing to their useful biological activity, highly complex structure and intriguing biosynthetic mechanisms. Following the original proposal for the polyepoxide origin of lasalocid and isolasalocid and the experimental determination of the origins of the oxygen and carbon atoms of both lasalocid and monensin, a unified stereochemical model for the biosynthesis of polyether ionophore antibiotics was proposed. Th...

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Publisher copy:
10.1038/nature10865

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Nature
Volume:
483
Issue:
7389
Pages:
355-358
Publication date:
2012-03-15
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:99848fcc-030c-4c49-ae41-ce37d2cc6689
Source identifiers:
316258
Local pid:
pubs:316258

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