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Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Abstract:

Polycyclic polyether natural products have fascinated chemists and biologists alike owing to their useful biological activity, highly complex structure and intriguing biosynthetic mechanisms. Following the original proposal for the polyepoxide origin of lasalocid and isolasalocid and the experimental determination of the origins of the oxygen and carbon atoms of both lasalocid and monensin, a unified stereochemical model for the biosynthesis of polyether ionophore antibiotics was proposed. Th...

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Publisher copy:
10.1038/nature10865

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Journal:
Nature
Volume:
483
Issue:
7389
Pages:
355-358
Place of publication:
England
Publication date:
2012-03-15
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
316258
Language:
English
Keywords:
Pubs id:
pubs:316258
UUID:
uuid:99848fcc-030c-4c49-ae41-ce37d2cc6689
Local pid:
pubs:316258
Deposit date:
2012-12-19

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