- Abstract:
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PURPOSE: Hyperpolarized metabolic imaging has the potential to revolutionize the diagnosis and management of diseases where metabolism is dysregulated, such as heart disease. We investigated the feasibility of imaging rodent myocardial metabolism at high resolution at 7 T. METHODS: We present here a fly-back spectral-spatial radiofrequency pulse that sidestepped maximum gradient strength requirements and enabled high resolution metabolic imaging of the rodent myocardium. A 3D echo-planar imag...
Expand abstract - Publication status:
- In press
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.4mb)
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- Publisher copy:
- 10.1002/mrm.25730
-
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- Grant:
- FS/10/002/28078; FS/14/17/30634; FS/11/50/29038; RG/11/9/28921
- Grant:
- LSI DTC; IT EP/J013250/
- Publisher:
- Wiley Publisher's website
- Journal:
- Magnetic resonance in medicine Journal website
- Pages:
- n/a-n/a
- Publication date:
- 2015
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- URN:
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uuid:9984075d-7b29-4771-90ca-e65ba458421b
- Source identifiers:
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525567
- Local pid:
- pubs:525567
- Language:
- English
- Keywords:
- Copyright holder:
- Miller et al.
- Copyright date:
- 2015
- Notes:
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Copyright © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 t with 3d spectral-spatial EPI.
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Funding
+ British Heart Foundation
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National Institute for Health Research Oxford Biomedical Research Centre
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+ Engineering and Physical Sciences Research Council
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John Fell Fund
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