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Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 t with 3d spectral-spatial EPI.

Abstract:

PURPOSE: Hyperpolarized metabolic imaging has the potential to revolutionize the diagnosis and management of diseases where metabolism is dysregulated, such as heart disease. We investigated the feasibility of imaging rodent myocardial metabolism at high resolution at 7 T. METHODS: We present here a fly-back spectral-spatial radiofrequency pulse that sidestepped maximum gradient strength requirements and enabled high resolution metabolic imaging of the rodent myocardium. A 3D echo-planar imag...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/mrm.25730

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Grant:
FS/10/002/28078; FS/14/17/30634; FS/11/50/29038; RG/11/9/28921
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
John Fell Fund More from this funder
Publisher:
Wiley Publisher's website
Journal:
Magnetic resonance in medicine Journal website
Pages:
n/a-n/a
Publication date:
2015
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:9984075d-7b29-4771-90ca-e65ba458421b
Source identifiers:
525567
Local pid:
pubs:525567

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