Journal article icon

Journal article

Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.

Abstract:

Clustered DNA damage induced by a single radiation track is a unique feature of ionizing radiation. Using a plasmid-based assay in Escherichia coli, we previously found significantly higher mutation frequencies for bistranded clusters containing 7,8-dihydro-8-oxoguanine (8-oxoG) and 5,6-dihydrothymine (DHT) than for either a single 8-oxoG or a single DHT in wild type and in glycosylase-deficient strains of E. coli. This indicates that the removal of an 8-oxoG from a clustered damage site is m...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Shikazono, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Mutation research
Volume:
669
Issue:
1-2
Pages:
162-168
Publication date:
2009-10-05
DOI:
EISSN:
1873-135X
ISSN:
0027-5107
URN:
uuid:9983ccac-8115-4caf-a54a-6582b183b916
Source identifiers:
131378
Local pid:
pubs:131378

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP