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A dual marker label free electrochemical assay for Flavivirus dengue diagnosis

Abstract:

Dengue is a RNA viral illness of the genus Flavivirus which can cause, depending on the pervasiveness of the infection, hemorrhagic dengue fever or dengue shock syndrome. Herein we present an electrochemical label free approach enabling the rapid sensitive quantification of NS1 and IgG (supporting an ability to distinguish primary and secondary infections). Using a bifunctional SAM containing PEG moieties and a tethered redox thiol, both markers are detectable across clinically relevant level...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.bios.2017.09.014

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Inorganic Chemistry
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Biosensors and Bioelectronics Journal website
Volume:
100
Pages:
519-525
Publication date:
2017-09-12
Acceptance date:
2017-09-11
DOI:
EISSN:
1873-4235
ISSN:
0956-5663
Pubs id:
pubs:737310
URN:
uri:998072ba-a019-48af-9845-097ab78d4783
UUID:
uuid:998072ba-a019-48af-9845-097ab78d4783
Local pid:
pubs:737310

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