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Cytotoxic T-lymphocytes against malaria and tuberculosis: from natural immunity to vaccine design.

Abstract:

1. Mycobacterium tuberculosis and the liver stage of Plasmodium falciparum are intracellular pathogens which are potentially susceptible to cytotoxic T-lymphocytes, a crucial component of the protective immune response to viral infections. Evidence from animal models points to a protective role for cytotoxic T-lymphocytes against M. tuberculosis and P. falciparum, but cytotoxic T-lymphocytes specific for these pathogens have been difficult to identify in man.2. Using a reverse immunogenetic a...

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Publication status:
Published

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Publisher copy:
10.1042/cs19980201

Authors


Lalvani, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Clinical science (London, England : 1979)
Volume:
95
Issue:
5
Pages:
531-538
Publication date:
1998-11-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:997d9d91-b81c-4889-9df5-184a4a418cd5
Source identifiers:
36244
Local pid:
pubs:36244

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