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Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task.

Abstract:
Aged (24 month) rats have previously been shown to manifest delay-dependent deficits in the performance of an operant delayed non-matching to position task. In the present experiment, cholinergic-rich grafts implanted into either the neocortex or the hippocampus of aged rats are shown to reinnervate the host neocortex and hippocampus, respectively, and to provide a significant amelioration of the host animals' short-term memory impairments. The results are discussed in light of the cholinergic hypothesis of geriatric memory dysfunction.
Publication status:
Published

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Authors


Dunnett, SB More by this author
Rogers, DC More by this author
Evenden, JL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Experimental neurology
Volume:
102
Issue:
1
Pages:
57-64
Publication date:
1988-10-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:997b1941-f7a6-40f2-8b03-b2cd5a245afb
Source identifiers:
24314
Local pid:
pubs:24314

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